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The data generated through this method allows predictions of function to be made for previously uncharacterized genes based on the observation that genes with similar function often show a common expression pattern.
In our data, many annotated unigenes having functions similar to histone H4 exhibited a common expression pattern.
In this way, we could determine whether Brg1-dependent genes demonstrate a common expression pattern during mesoderm induction.
Based on phylogenetic analysis, we concluded that the GmGER genes did not share a common expression pattern.
To increase the likelihood to identify HCV-modulated genes, we selected probes showing a common expression pattern in both 1 and 2 datasets.
Cluster 2 genes present a common expression pattern characterized by up-regulation in 24 h followed by down-regulation in 48 h.
Similar(45)
In contrast, CLUSTER analysis did reveal a number of gene groups (the enlarged portions of Figs. 3 5) that share a common expression patterns characterised by a directional change in gene expression relative to MEF WT cells, in one or both of MEF C/EBPβ −/− and/or MEF C/EBPδ −/− cells, indicating a dependency on C/EBPβ and/or C/EBPδ for the expression change.
Earlier it had been shown that utrophin, a cytoskeleton protein, shares the common expression pattern of Dp71, Kir4.1, and AQP4.
Gene expression data from DNA microarrays is represented by multiple, summary measures that we term metagenes; each metagene characterizes the dominant common expression pattern within a cluster of genes.
Conversely, miRNAs within the same genomic region that share common expression pattern would predict that these miRNA genes are transcribed as a polycistron.
The most common expression pattern was induction in response to pathogen infection and to a lower extent with wounding, similarly to that found in macroarray hybridization data.
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