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Most of the algorithms used to predict Q/N-rich prion candidates [ 30, 36- 38] have a common downside: they lack of a proper statistical calibration of the methodology and thus an estimation of the predictive capability of the model to scan sequence databases.
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As an image-maker of genius, he came with the common downside of sometimes sacrificing use to look.
One of the common downsides when using any sort of handset case or skin is that you often lose compatibility with accessories.
Two of the most common downsides are panic attacks and the fact that they taste like eating out an ass.
The IFA letter referred several times to "low downside risk" (a common Aaron phrase) But they lost most of their money.
On the downside – and this was a common problem in central London pubs – I could have done without the naff background music.
All in all, a return to the Commons may have a downside for Boris, but it would be all upside for everyone else – in the Conservative party, at any rate.
But running has a downside: Injuries are common.
Yet here again, there is a downside: privileging consensus favours the lowest common denominator and status quo thinking.
For that premium you buy both a nice yield (6.25%, as opposed to 1.6% on the common) and some downside protection if Bunge's stock falls further.
But the avarice has a potential downside.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com