Sentence examples for a common aberration from inspiring English sources

To delineate the functional outcome of chromosome 8p loss of heterozygosity (LOH), a common aberration in breast cancer, we modeled 8p LOH using TALEN-based genomic engineering.

Loss of 8p is a common aberration in breast tumors, and several loci on 8p have been suggested to harbor tumor-suppressor genes [ 62].

Loss of PTEN is a common genomic aberration in castration-resistant prostate cancer (CRPC) and is frequently concurrent with ERG rearrangements, causing resistance to next-generation hormonal treatment (NGHT) including abiraterone.

Loss of PTEN is a common molecular aberration in PCa and believed to be critically important in regulating AR signaling output [5,13,14].

An association between the 677C→T substitution in MTHFR and hyperdiploidy, a common cytogenetic aberration in childhood ALL, has also been demonstrated (Pui et al, 2004).

CDKN2A loss is a common genetic aberration in metastatic GIST [ 94], and several studies show an association between low tumor p16ink4 (the gene product of CDKN2A) and frequent response to cyclin-dependent kinase (CDK) 4/6 inhibitors [ 95].

Recent cytogenetic analysis of canine OSA revealed breed independent myc amplification in 40% of the cases, suggesting this is a common chromosomal aberration in both canine [ 9] and human OSA [ 50].

9– 11 A common epigenetic aberration in cancer involves deregulated DNA methylation such as cytosine-phosphate-guanine (CpG) island hypermethylation that leads to gene silencing of specific tumor-suppressor genes.

The most common aberration in prostate cancers was a gain of chromosome 8 (57%), with numerical aberration of chromosome 7 being the second most frequent anomaly (50%).

Tumors from six patients had common aberrations (Table 2, common aberration).

The most common aberration observed in chromosome 20 was deletion of the short arm.