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Meis1 was 1.8-fold downregulated after Sp1 knockdown in Flk1+ and progenitor cells (supplementary material Table S1), raising the possibility of a combined negative effect on hematopoietic development.
In PromoBot--which used a combined negative dataset in which only 40 non-redundant rRNA sequences are included--the overall performance was higher than the case of using only mRNA or miRNA as negative set.
The authors' concern regarding the effect of giving a combined negative chronotropic and inotropic agent on cardiac output and microvascular blood flow led them to perform a pilot study.
Comorbid physical and mental health conditions can show a combined negative impact on disease-related outcomes [ 7, 15].
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Therefore, in spite of a large positive coefficient of GSTM5, the combined negative effect of GSTM1 and GSTM4 on the cytotoxicity is expected to dominate.
Two years ago, a surfing contest was canceled near the Trestles, a famed surf spot near the Orange-San Diego county line, because of the combined negative impact of rattlesnakes and water pollution.
"This survey demonstrates the combined negative impact of the accountability agenda on teacher workload and morale.
Both Tesla and Solar City are burning through considerable amounts of cash in order to build their businesses last year, their combined negative cash flow was around five billion dollars.
Dara P. Richardson-Heron: Unfortunately, many women face tremendous challenges based on the combined negative impacts of their gender, race, and lack of economic parity.
General secretary of the NUT, Christine Blower, said: "This survey demonstrates the combined, negative impact of the accountability agenda on teacher workload and morale.
By April 2010, BG had combined negative assets, debt and received grants of NOK 240 million.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com