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The HRs for suicide and suicide attempt were nearly identical in all separate and combined analysis and are therefore presented as a combined end point if not otherwise specified.
Cumulative event-free survival was evaluated for a combined end point, defined as death from any cause, urgent transplantation, or implantation of a left ventricular assist device.
A second limitation in that study is the choice of a combined end point.
Because the frequencies of each adverse outcome were small, we chose a combined end point for our intervention study.
Interestingly, fewer pioglitazone patients with serious CHF had a combined end point of death, MI, or stroke compared with placebo patients (34.9 vs. 47.2%; P = 0.025).
Rice et al had a combined end point of emergency department visit or readmission to hospital, with no significant benefit in terms of readmission alone.
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We aimed to identify risk factors for a combined end-point of death and/or prolonged ventilator dependence and developed an ALI-specific prediction model.
For the first time, according to our knowledge, we evaluated the effect of PTX3 levels on the development of a combined end-point of left ventricular dysfunction (EF < 40%) or mortality at one year.
A model based on age and cardiopulmonary function three days after the intubation is able to predict, moderately well, a combined end-point of death and/or prolonged mechanical ventilation in patients with ALI.
In a prospective cohort study of 230 patients undergoing chronic peritoneal dialysis, Wang et al. reported that NT-pro-BNP was an independent risk marker of congestive heart failure, death, or a combined end-point including death and other adverse cardiovascular outcomes [ 22] (odds ratios varied between 4.25 and 9.1 for the fourth compared to the 1st quartile of NT-pro-BNP).
Based on its analysis of seven randomized controlled trials that met pre-specified criteria, the meta-analysis demonstrated highly significant benefits of noninvasive positive pressure ventilation in COPD patients, including a reduction in a combined end-point consisting of death and endotracheal intubation.
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