Any combination that increases an asymmetry in gene flow between northern and southern populations will enhance the genetic cline, while symmetry will tend to even out the effects of northern and southern gene flow.
All the above agents are often dosed as un-fixed combinations that increase dosing complexity and the likelihood of adverse events.
The effect of covariate combinations that increase apixaban exposure (female gender, age > 75 years, cCrCL < 30 ml/min, and body weight < 50 kg) would be expected to increase bleeding risk by 11% (Table 1 ).
Island and coastal areas in northern and western regions of Scotland are characterised by comparatively high levels of wind and rain — a combination that increases the wind-chill cooling of buildings and leads to higher energy consumption.
Porous implants are known to promote cell adhesion and have low elastic modulus, a combination that can significantly increase the life of an implant.
These drinks are also frequently combined with alcohol, a combination that has been found to increase alcohol consumption in laboratory animals [103].
The development of a combination therapy that increases the efficacy of TAM has been investigated in several studies, using vitamin E [ 8] and green tea [ 9].
Matilda and her classmates have good reason to forget or not care about Tiananmen and May 4th: there are more opportunities and distractions available to them than ever, while the intense pressure of competition to succeed in a tight job market only increases - a combination that keeps most too busy to think about politics at all.
It took a coalition of political support and a combination of measures that increased income, especially in families with young children (minimum wage, paid maternity and paternity leaves, tax credits), and better services — especially universal preschool programs.
Because the CHORUS search of combinatorial space is directed towards combinations that increase PAI, our approach is less susceptible to identifying combinations comprised of variables that are completely redundant with each other.
