Thus, HyPer fills an important niche in examining homeostatic control of H2O2 due to a combination of sensitivity, specificity and reversibility.
Using a combination of the specificity of reciprocal ETA, which achieves the near 100% predictive accuracy, and the sensitivity of non-reciprocal ETA, which provides additional results, yields a desirable balance of sensitivity and specificity for functional annotation.
In this case, nature has achieved a combination of high specificity with fast interaction rates.
These, and the corresponding biochemical data, indicate how E. coli PheRS has evolved to effectively discriminate against different Tyr isomers using a combination of substrate specificity (o-Tyr, p-Tyr) and editing activity (m-Tyr, p-Tyr).
We have reviewed published evidence suggesting that phosphatases select their substrates by a combination of enzymatic specificity (e.g., tyrosine phosphatases) and spatial organization, mediated by the protein interaction network that modulates subcellular co-compartmentalization and substrate docking.
Since it is likely that P. ramosa isolates consist of more than one clone, some of which may be incompatible with the D. magna clone used in this experiment, we conjecture that a combination of proliferation specificity and inter-clone competition may explain why P. ramosa clones produced more spores than isolates.
The synthesis of PLs (Kennedy pathway) and remodeling pathway (Lands' cycle) is a complex pathway, and therefore, our results probably reflect a combination of known specificities of multiple acyl-CoA:lysophospholipid acyltransferases (46) and CoA-dependent transacylases (30, 56).
Arrays can be designed with a combination of high-specificity probes and probes designed against conserved regions, so that they can be used in both detection and discovery modes.
An RKPT-enriched region is defined by the presence of at least 3 carbonylatable sites within a 4 amino acid sequence window, resulting from an optimal combination of specificity and sensitivity (supplementary Table S1).
The described application serves as a model for the development of rapid, molecular detection systems that offer an unprecedented combination of specificity, high throughput capabilities and robust target quantification.
