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However, when a mechanism is less understood or is a combination of effect mechanisms, it will be more challenging to make translational predictions and simpler approaches should be adopted that rely on fewer assumptions.
Characterization factors (CFs) were calculated as a combination of effect (EF) and fate factor (FF, relating water consumption to wetland area loss) (eq 4) for each taxon p and for each wetland k.
22 An improvement in single-word intelligibility of greater than or equal to 14% was deemed to be an MCID 22 based on a combination of effect size and SLPs' observations of functional improvements in intelligibility skills.
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It has anti-inflammatory, endocannabinoid-modulating and antioxidative properties, combined with low toxicity, hence provides a combination of effects that make it prone as a potential MS therapeutic.
The combined effect of the double mutant may indicate a combination of effects associated with loss of both histone H3K9 and H3K14 acetylation.
The effectiveness of the drug has been attributed to a combination of effects, including the blockage of repetitive neuron firing through an interaction with sodium channels.
A combination of effects have created a perfect storm," Coupe said.
The drug seems to work through a combination of effects that reduce inflammation in the brain and encourage the growth of fresh neurons in a key region called the hippocampus.
A combination of effects can typically lead to errors of 85% in the estimation of net vertical heat flux.
These include fat crystal-induced partial coalescence, protein-induced (bridging) flocculation, coalescence or a combination of effects.
These findings, taken together, may suggest that DHE-induced vasopresponsessponses involve the sum of a combination of effects mediated by activation of 5-HT2A receptors, α1-adrenoceptors and α2-adrenoceptors.
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