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The phrase "a combination of difficulties" is correct and usable in written English.
It can be used to describe a situation where multiple challenges or problems are present at the same time.
Example: "The project faced a combination of difficulties, including budget constraints and staffing shortages."
Alternatives: "a mix of challenges" or "a series of obstacles".
Exact(1)
We encountered significant delay in opening recruiting centres due to a combination of difficulties in obtaining high-quality data for quality assurance assessment and securing approval from respective host organisations.
Similar(57)
All 25 patients that failed initial macular hole surgery and were not re-operated on declined re-operation either for personal reasons (a combination of difficulty with face-down positioning along with guarded prognosis) or deferred their decision to think about it and did not get back to their surgeon within a year of primary surgery.
Regardless of acute clinical symptoms, WNV case-patients in this study continued to report difficulty walking, muscle weakness, fatigue, and insomnia, with >40% reporting a combination of these difficulties, and 30% continued to report persistence of memory loss, confusion, depression, and irritability at 18 months after acute illness.
This was likely due to a combination of legal difficulties and changes in the woman's circumstances, he said.
He said: "It reflects a combination of the difficulties some rural authorities have with recruitment outside the central belt and the appalling lack of teaching posts in the Republic and Canada".
The campaign then slowed owing to a combination of logistical difficulties and Japanese resistance.
Social care and healthcare are consistently ranked as among the most stressful fields to work in – perhaps due to a combination of the difficulty of the work itself, budget cuts, a high turnover of employees, and staff shortages.
The trouble is, that system is mostly hidden from the outside world by a combination of language difficulty and the pitch-dark opacity that envelops much important business here.
A gymnast's performance is evaluated by a jury according to rulebooks, which include a combination of the difficulty level, execution and artistry.
The three categories of admission are not reported separately because children could be diagnosed with a combination of breathing difficulty, feverish illness, and diarrhoea during a single admission.
It's an odd place to holiday, but the burning purpose of this pilgrimage is to visit the nearby shrine, where it is hoped that Hanny, who has a condition that seems to be a combination of severe learning difficulties and muteness, might be cured.
More suggestions(16)
a combination of conditions
a combination of efforts
a combination of disorders
a combination of disadvantages
a combination of odds
a combination of sensitivities
a number of difficulties
a variety of difficulties
a headache of difficulties
a result of difficulties
a succession of difficulties
a maze of difficulties
a string of difficulties
a lot of difficulties
a slew of difficulties
a barrage of difficulties
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com