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The phrase "a colossal difference between a" is correct and usable in written English.
It can be used when discussing a significant distinction or disparity between two or more subjects.
Example: "There is a colossal difference between a good leader and a great leader in terms of their impact on the team."
Alternatives: "a significant difference between a" or "a vast difference between a".
Exact(1)
No. Martín Demichelis would still have been sent off, and Barça would have had a dangerous set piece, but there's a colossal difference between a penalty and a free-kick … and yet there is often very little difference in the fouls that see them awarded.
Similar(59)
And having her coming every Friday, you know, it's a colossal difference' (Erica).
By sticking to a small-sounding number, Rove is simply avoiding history's inevitable judgment on the colossal difference between Obama's convincing victory this month and Bush's narrow 2004 win.
"It was a world in which there were colossal differences between the very poor and the very rich, and not much in between; also a world bedevilled by dictators and corruption," he said.
The Tech Love-In highlighted the colossal differences between Google and Apple.
"Obviously it made an absolutely colossal difference.
When I helped run a measles immunization program in West Africa in the 1960s, I learned that in global health small things can spell the difference between a major success and a colossal failure.
It was a colossal shift in the defense strategy and I believe it made the difference between a guilty verdict and an acquittal.
The difference between a triolet.
Think of the difference between a Megan Fox and Mariah Carey.
But there is a difference between them.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com