Entry 25: This database contains a collection of known active reference compounds, newly identified actives (hits), and screening database information extracted from original literature sources reporting prospective LBVS applications.
Here, we build a collection of the active ligands from BindingDB for FDA-approved drug targets from DrugBank [41].
We illustrate the tool by examining a diverse set of structural changes within a collection of molecules active against the HIV Integrase enzyme.
Hence, what we are calling a metabolic reconstruction (a collection of the active variants of subsystems that have been identified) is more properly thought of as a grouping of genes into modules, rather than the reconstruction of the metabolic network.
Thus, within the genome is a collection of hotspot-active DNA sites and a reservoir of "cryptic" DNA sequence motifs that can be rendered active by as little as a single-base-pair substitution.
Interestingly, similarity searches do not require a diverse collection of active and inactive molecules prior to be used.
The LOPAC library is a collection of 1,280 pharmacologically active compounds from 56 pharmacological classes with well-characterized activities.
Phosphoinositides (PIs), a collection of seven biologically active and interconvertable phosphatidylinositol derivatives, are minor yet essential components of the cytosolic leaflet of eukaryotic cell membranes.
The largest drug manufacturer in Uganda is Kampala Pharmaceutical Industries (KPI), owned by the Aga Khan Development Network, a collection of development groups active primarily in Asia and Africa.
The ICCB library is a collection of 472 diverse biologically active compounds with defined biological activity developed at the Harvard Institute of Chemistry and Cell Biology.
The resulting schedules are a collection of transmission modes (sets of active links) that are time shared in a fashion that is reminiscent of spatial reuse patterns in cellular networks.
