This points out that pathogenicity predictions should always be treated with caution and that functional validation of variants is of paramount importance to clarify their role in contributing to phenotype, especially in the context of specific haplogroups and upon taking into account that penetrance is a cogent clinical issue particularly in canonical mitochondriopathies such as LHON.
It focuses on the concrete impact of their actions, but doesn't address the more cogent issue of conduct unbecoming persons of high responsibility - people we entrust to make important decisions.
Ad hominem aside, most of the cogent issues were actually addressed in the article.
There are lots of cogent issues we need to prudently consider with robot intelligence, but the next time you play a role in making some news item go viral, at least stop and consider the basis for your distrust of the AI in the story.
More importantly, the debate surrounding this event has awakened research scientists to the cogent issues involving biosecurity and biosafety in research on emerging infectious pathogens.
Quotations were selected by the lead author as being a cogent representation of an issue assigned to a particular theme, and independently confirmed as such by the other authors.
Eeven if it were a quiet day, he'd have an interesting take or a cogent fact on the latest issue, or occasionally a delicious-sounding recipe.
But I was afraid of the conclusion I might draw, that the expression was not pretentious jargon, that the expression made sense, opening out into a cogent argument concerning important issues.
Undergraduate training is responsible for promoting a significant increase in the growth and development of moral reasoning in medical students [ 7] and should offer students the tools to analyze ethical issues and to formulate a cogent and well-defended position without, however, dictate a particular substantive outcome [ 11].
LAST week, I spent most of an afternoon trying to get a cogent explanation of a confusing news release issued late on the Friday before New Year's by a mouthful of an agency called the United States Department of Transportation Pipeline and Hazardous Materials Safety Administration.
