Sentence examples for a cluster of mutations from inspiring English sources

The signature analysis of each subclone, represented by a cluster of mutations identified by the Dirichlet process, was limited to clusters with more than 100 substitutions.

A cluster of mutations in the presence of the drug usually indicates a plausible region of drug target interaction.

Positive selection for protein function can lead to multiple mutations within a small stretch of DNA, i.e., to a cluster of mutations.

H1 and H3 were the most frequent haplotypes observed in the study population and they share a cluster of mutations (Figure 1).

HIV resistance to AZT is commonly associated with a cluster of mutations in the reverse transcriptase, known as TAMs (thymidine analog mutations).

One peak resulted from strong covariation between a cluster of mutations RT 41L and 43E with another cluster RT 208Y and 210W; while the other peak reflected strong covariation between a cluster RT 67N and 70R with the cluster RT 208Y, 218E and 219E/ Q

Indeed, TCGA mutation data showed a cluster of B2M mutations at Ser14 (Supplementary Fig. 12a).

A cluster of eight mutations in a central region spanning residues 184 296 with exclusively destabilizing effects was evident.

We used plasmid shuffle to introduce rpn1 alleles into a mutant, rpn10-uim, in which the UIM domain is inactivated by a cluster of point mutations [ 41, 42].

A cluster of inactivating mutations (n = 10) was located in exon 31 between codons 1021 and 1065 (Table  1) the significance of which is not known.

Third, the active site was reshaped by a subtle ∼1.0 Å shift of Leu106 and Trp131, which was likely triggered by a cluster of remote mutations occurring in the same loops (s102T, l130V, m138I, s137T, and v140M, Figure 7D, and Figure 2 figure supplement 1C).