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The hypothyroxinemia correlated to a cluster of developmental parameters including delayed sexual development in females, decreased pup mortality, and effects on brainstem auditory evoked potentials [Lilienthal, H., Verwer, C.M., Van der Ven, L.T.M., Piersma, A.H., Vos, J.G., 2008. Neurobehavioral effects of tetrabromobisphenol A (TBBPA) in rats after pre- and postnatal exposure. Toxicology].
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It was associated with a cluster of other dentate developmental abnormalities that reflect defective neuronal proliferation, migration, and/or survival.
The bithorax complex in Drosophila melanogaster is a cluster of homeotic genes that specify developmental pathways for many of the body segments of the fly.
The handful of genome level studies conducted on sharks have already revealed some distinctive features, including the absence of the HoxC cluster of developmental pattern genes found in all other non-elasmobranch vertebrate lineages [ 7], and the presence of a substantial number of expressed sequence tags for which no homologues in other organisms could be identified [ 8].
A cluster of pathologies?
"Sometimes you see a cluster of them.
A cluster of barnacles?
Find a cluster of daffodils.
From a large group of patients with type 2 diabetes (N = 3,343), the authors identified five clusters of developmental patterns of DR. The largest (cluster A) included patients who did not develop any form of DR over a 6-year period ("persistent no retinopathy").
Importantly, spatial clustering of developmental genes is fundamental for the correct regulation of gene expression during early development.
K-means clustering of developmental transcriptomes.
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