The phrase "a closed configuration" is correct and usable in written English.
It can be used in contexts related to systems, structures, or arrangements that are not open or accessible, often in technical or scientific discussions.
Example: "The experiment requires a closed configuration to ensure that no external variables affect the results."
Alternatives: "a sealed arrangement" or "an enclosed setup".
The strength of the promoter- enhancer interaction is likely to be primarily mediated by the epigenetic state of the enhancer, i.e. a closed configuration by recruitment of repressive marks leads to a weaker interaction.
Brunet says this is likely because, without this protein, the DNA is in a closed configuration and less accessible to the cellular machinery that allows genes to be expressed.
In the absence of the target ss-DNA, the fluorescent probe stays a closed configuration in which the P-dC is located in the double strand stem of the fluorescent probe, such that there is weak fluorescence, attributed to a more efficient stacking and collisional quenching of neighboring bases.
From the structure, we discuss how a consolidated FN5 can serve as the key netrin-1 binding domain, and how a closed configuration, where the FN4 domain "lies" on the rod-like FN5-FN6 domains, can be proposed as a resting state of the DCC receptor for stability.
The "lid" contributes to provide an open and a closed configuration to the enzyme.
In colorectal cancer, chromatin at promoter regions of tumor-suppressor miRNAs show a closed configuration, producing a repressed transcriptional state.
For example, Lys63 ubiquitin chains have a more-linear configuration, whereas Lys48 chains have a more "closed" configuration, so these two different chain types span a range of potential topologies.
Atolls consist of ribbons of reef that may not always be circular but whose broad configuration is a closed shape up to dozens of kilometres across, enclosing a lagoon that may be approximately 50 m (160 feet) deep or more.
Even under nutrient-rich conditions and rapid growth, the rDNA repeats in each cell exist in two different chromatin states, with approximately half in a transcriptionally active "open" configuration and the others in a transcriptionally inactive "closed" configuration (Conconi et al. 1989; Dammann et al. 1993).
The IgE-Fc adopts a more compact, closed configuration that places the two Cε3 domains in close proximity, decreases the size of the interdomain cavity, and obscures part of the FcεRI binding site.
But with regard to dusty condition, no definite conclusion could be drawn except that all sides closed configuration may prevent dust.
