Hence, a priori, a close linkage is expected between regional- and local-scale factors.
For a successful purging strategy where a transgene is placed in close linkage with a gene or genomic block that causes a lower fitness in the wild habitat (Gressel 1999; Stewart et al. 2003), clear indications are needed of those negatively selected regions.
Alternatively, if a transgene is placed in close linkage with a gene or genomic block that causes a lower fitness in the wild habitat compared to the wild relative, it will have a smaller chance to introgress (Gressel 1999; Stewart et al. 2003).
A purging mitigation strategy was already experimentally tested in tobacco (Al-Ahmad et al. 2004) and oilseed rape hybrids (Rose et al. 2009), where a transgene was placed in close linkage with a dwarfing gene.
Using the minimum wage's close linkage with a less-educated worker's expected income, I find that in addition to being an important component of wages, a minimum wage increase can induce migration.
It has therefore been suggested that transgenes placed in close linkage with an allele that is selected against in the wild are more likely to be purged from the wild population (Gressel 1999; Stewart et al. 2003); we will refer to this mitigation strategy as a 'purging strategy'.
This phenomenon may be due to an alternative hypothesis that HLA may only be a genetic marker, which is in close linkage with another NPC predisposition locus.
What might be the physiological importance of mitonuclear coevolution in complex I? Remarkably, genetic variants in close linkage with NDUFC2, a subunit which physically interacts with the mtDNA-encoded complex I subunit ND4, were recently associated with decreased glucose-stimulated insulin secretion (Olsson et al. 2011).
A single recessive gene, bph2, derived from ASD7 showed close linkage with Bph1 gene and no recombination between them was observed.
