The phrase "a close linkage to" is correct and usable in written English.
It can be used when discussing the relationship or connection between two or more concepts, ideas, or entities.
Example: "The research findings indicate a close linkage to environmental factors affecting health outcomes."
Alternatives: "a strong connection to" or "a tight relationship with".
This possibility agreed with Southern blot analysis performed on a separate sample of 32 other colonic carcinomas in which the diallelic loss of D1S58 (which exhibits a close linkage centromerically to PIGR) was calculated to be 6.4%.
Thus, these intervals of genetic heterogeneity might reflect close linkage to a true causal polymorphism that is maintained by selection in different lineages.
Such an expectation may fail to recognize the historical legacy of the authoritarian Salazar regime, which, while keeping close linkage to the Catholic Church, was quite a state centered regime that did not allow strong independent community action.
Sediments are an important topic for many scientists and regulatory authorities due to their close linkage to the aquatic food web and their potential for accumulating pollutants.
Although one other site (site 29) showed moderate but statistically significant immunoprecipitation, its close linkage to site 29 makes ancillary immunoprecipitation from incomplete DNA shearing a likely explanation.
Nine pairs of candidate reads displayed close linkage to other candidates, all mapped to mRNA exons.
All loci are from chromosome arm regions, excluding pericentromeric region genes where close linkage to other loci could affect their diversity [28].
Another criteria that may increase our confidence in candidates representing miRNAs rather than other types of ncRNA could include close linkage to known miRNAs (<5000 bp).
This is supported by the close linkage to HoxC and HoxD which are assumed to be duplicate loci.
