Although this drop in scores at 24 months might be attributed to a lack of developmentally stimulating environments, it is also possible that the Bayley Scales, although having internal validity in our population, may not be a clinically valid tool in Spanish or in Latino immigrant communities.
22 While this is the measure of choice in the UK for mental well-being, it is not a clinically validated measure of mental illness, but there is a high inverse correlation between WEMWBS scores and scores on the Center for Epidemiologic Studies Depression Scale (CES-D), a clinically valid measure of depression, widely used in population-based studies.
Therefore, temporary epicardial pacing devices set at a clinically valid threshold may not detect abnormally wide QRS waves without omission.
To develop a clinically valid interactive level 2 screening assessment for autism spectrum disorders (ASD) in toddlers that is brief, easily administered, and scored by clinicians.
In this context, survival of patients without their disease getting worse (i.e., PFS) is recognized as a clinically valid endpoint for survival and will represent an acceptable primary endpoint in the eyes of the regulatory agencies e.g. if subsequent therapies have an impact on OS [2].
An optimal modelling of predictors is crucial to achieve a clinically valid prediction model.
To test these recommendations, we had to create a clinically valid definition for this patient population.
The Modified Tardieu Scale is considered a clinically valid measure for the assessment of spasticity.
To translate into a clinically valid marker, a risk factor has to be very strongly associated with a trait.
All five subscales from the KOOS will be included individually as secondary outcomes to support a clinically valid interpretation of the result.
Thus, the revised primary outcome is a clinically valid hard endpoint associated with increased patient morbidity and mortality as well as health care costs.
