Suggestions(2)
Exact(5)
In this model, ND-drug exhibited anti-tumor efficacy comparable to nab-paclitaxel, a clinical formulation.
CPT-11 was provided by Pfizer as a clinical formulation.
Atropine (0.6 g l−1) was a clinical formulation.
Indeed, based on the results reported here, a clinical formulation of topical ophthalmic MTP-131 (Ocuvia) has entered a clinical trial for treating diabetic macular edema.
We conclude that a clinical formulation of AmphoB, AmBisome, produces the functional equivalent of an Ifitm3-null state, and by so doing converts a mild illness into a life-threatening infection.
Similar(55)
Taxol is an FDA-approved clinical formulation of paclitaxel (PTX) in which a Cremophor EL/ethanol (1 1, v/v) mixture is used to solubilize PTX; however, Taxol can cause hyperactivity reactions, neuropathy, and other serious side effects.
Cyclophosphamide and CDDP Bristol-Myerss Squibb Co., Princeton, NJ, USA) were used as a ready-to-use clinical formulation solution in 50 100 ml vials that contained 1000 mg of CTX (20 mg ml) and 100 mg of CDDP (1 mg ml−1), respectively.
Irinotecan was purchased from Pfizer Inc. (New York, NY, USA) as a ready-to-use clinical formulation solution in 5 ml vials containing 100 mg of the drug (20 mg ml−1).
To accelerate clinical formulation development, an excipient compatibility screen should be conducted as early as possible and it must be rapid, robust and resource sparing.
Although the current clinical formulation of paclitaxel (Taxol®) has a promising clinical activity against a wide variety of tumors, it has significant toxic side effects, some of which are associated with its formulation in a 1 1 (v/v) mixture of Cremophor EL and dehydrated alcohol.
Further the proof of concept is utilized in the assay of atropine sulphate present in clinical formulation (eye drop) with a sensitivity of 0.02 μA/μM, and limit of detection as 72.50 nM.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com