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A similar relationship could be demonstrated for TSP-1 and Il-1RII with a clear reduced response to the applied Dexamethasone that could be significantly reversed through the addition of DIMS0150.
A PD transgenic model via Thy-1 promoter mediated α-synuclein over-expression exhibited several circadian phenotypes in aging: a clear reduced wheel-running activity with altered period, altered temporal distribution of sleep, and decayed spontaneous neural activity in the SCN, suggested circadian rhythm is severely disrupted in the PD model (Kudo et al., 2011).
Despite the finding that the number of HSCs was not different in the bone marrow of ptpn11 +/− and wild-type mice, these studies showed a clear reduced repopulating activity of the ptpn11 +/− HSCs that was associated with diminished HSC self renewal.
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In the BY4742 and ER7A backgrounds, which lack the smp1 R110Q,P269Q and hot1 P107S,H274Y alleles, the gpd1 L164P allele had a clear reducing effect on glycerol yield compared to the wild type GPD1 allele.
Addressing businessmen and women at a dinner, Clegg made it clear reducing Britain's debt is a major priority for the Lib Dems, arguing a lack of continued spending restraint would saddle future generations with an "unbearable" burden.
The solution seems clear: Reduce the corporate tax rate and eliminate the loopholes.
Our obligation is clear: reduce the risk of gun homicide and suicide in Georgia.
"The government and higher education sector now faces a clear choice: reduce student numbers or increase funding for HE," Wellings said.
There was a clear trend towards reduced SERT BPND in CD patients with psychiatric symptoms compared to those without (p = 0.05).
Possible explanations for the inability to detect a clear relationship between reduced RNA quantity and the increased duration of PMI in human tissue studies include the confounding effects of greater inter-subject variability and agonal or neuropathological variables on RNA degradation (Catts et al., 2005).
In summary, we used the tet-off system to provide a clear demonstration that reduced transcriptional potential can sensitize a promoter to undergo epigenetic silencing.
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