A clear drawback of vipR over the Poisson model and VarScan is the requirement for more than one DNA pool in order to facilitate screening for sequence variants.
Nevertheless, a clear drawback is the need for specifying a model although its parameters are estimated by the method.
Those findings outline a clear drawback in the use of biocatalysts for applications that require prolonged exposure to organic solvents, and showed the need for understanding the mechanism of enzyme inactivation during storage in these media.
Nevertheless, using such a limit presents a clear drawback, since δ has to be computed for each database before applying the algorithm (see section Biclustering approaches based on Evaluation Measures).
The "bottom up" approach, historically used by biologists, brings together all the known pieces at a subsystem level with the objective of identifying a formal structure of the whole system; a clear drawback is that it does not account for possible unknown factors.
"Check out this guy," said the sergeant, pointing to a man with a strange facial deformity, a clear drawback in his profession.
Such clear drawback is the main motivation for searching a new, active under visible-light-driven and more efficient photocatalysts [8-10].
However, these findings have the clear drawback of being extrapolated from studies carried out for different purposes.
The clear drawback of such viewing, however, is that bingers have had to wait until conventional once-a-night or once-a-week audiences finish with the show on their steam-powered linear networks for all episodes to be available.
