8 Community-based studies of MSM present great challenges, namely when it comes to defining a sampling frame, 9 due to the clear difficulty in establishing the boundaries of the target population itself because of cultural, anthropological and sociological reasons.
Typical data mining algorithms require having all data in main memory this is a clear technical difficulty for Big Data which is spread across different locations.
The clear difficulty with this solution, other than the fact that it has not seemed to be effective, is that we are all on information overload such that more information being produced leads to less information being digested.
A separate literature documents clear difficulties in emotionality, emotion regulation, and emotion-relevant impulsivity within bipolar disorder, and demonstrates that these emotion-relevant variables are also central to outcome.
This would indicate that in these patients there are clear difficulties in making a correct diagnosis rather than a lack of relevant expertise.
Kids with clear difficulties are referred to a speech pathologist for a more detailed evaluation.
Although Gleason grading is a useful clinical method, there are clear difficulties with inter-observer variation.
Because of these clear difficulties, the child narrator is an aspirational device for the increasingly confident writer.
"In addition, there are very clear difficulties in gathering and adducing evidence in these circumstances in the context of Parliamentary Privilege.
As we will see, Locke's initial views do suffer from clear difficulties that are remedied by his later change of mind, all without introducing incoherence.
