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In conclusion, our results demonstrate that the combination of H342 staining with UV irradiation has a clear deleterious effect on the developmental ability of oocytes, with the effects being more intense with increased exposure to UV irradiation.
This data demonstrates a clear deleterious effect of mDUX on myoblasts, very much like that exhibited by DUX4 when expressed at high levels [12], [14].
The genetic region that in our study was associated with a clear deleterious effect in males, caused overdominance in females.
Similar(57)
Also, catalytic residues were excluded because mutations of catalytic sites would have clear deleterious effects independent of their effect on the free energy of folding.
Except for one patient-specific missense mutations (c.196A>T in NM_018325.3 [p.Thr66Ser]) without a clear in silico deleterious effect, no other pathogenic mutations were identified.
Reduced sensitivity to inherited mutations slows the rate at which natural selection clears deleterious mutations from the population.
Thus, cases of persisting or progressing IAH require a clear therapy strategy to prevent the deleterious effects of subsequent ischemic damage, BT, and MOF.
In summary, there is not a clear picture about the beneficial or deleterious consequences of TLR5-flagellin interaction in vivo.
On the other hand, also mtDNA carrying deleterious mutations can have a clear replicative advantage over the wild-type mtDNA.
The discovery of a sufficiently sensitive and specific biomarker for the nonsurgical detection of endometriosis promises earlier diagnosis and prevention of deleterious sequelae and represents a clear research priority.
Additionally, the authors reveal a clear loss in transmission which is reproducible and consequently not deleterious to quantitation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com