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The phrase "a clear cut increase of" is correct and usable in written English.
It can be used when describing a noticeable or significant rise in a particular metric or value.
Example: "The report indicated a clear cut increase of sales in the last quarter, highlighting the effectiveness of the new marketing strategy."
Alternatives: "a significant rise in" or "a marked increase in".
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Thus, at 4 weeks post-infection, a time point at which mutant-Htt-induced cell loss is minimal in this model [11], we observed a clear cut increase in the number of small neuropil-like aggregates in older rats as compared to younger rats.
Moreover, a clear-cut increase of the -CH = CH- resonance (at 5.34 ppm) indicated that these chains were partially unsaturated.
TMS/EEG measurements revealed a clear-cut increase of frontal cortical excitability after ECT as compared to baseline, that was significant in each and every patient.
A clear-cut increase of CD40 mRNA was observed after incubation of the LAN-5, SK-N-SH, SK-N-BE 2(C), and ACN cell lines, but not in the SK-N-BE cell line, with rIFN- γ.
Indeed, a clear-cut increase in levels of NOS type II protein was observed when cells were co-stimulated with leptin and IL-1 (Fig. 1b).
Discordant class: This class (213, 19%) is the largest of the suboptimal classes and consisted of individuals with a clear-cut increase in the probability (11%39%%) of being exposed to each of the indicators of family adversity, with the exception of a very low rate of overt abuse/criminality (2.4%) but a higher rate of family discord, at 47%.
Our results show that 4 weeks post-infection with lenti-Htt171-82Q, there is a clear-cut increase in the number of neuropil aggregates in older animals.
The type 1 profile corresponded to normal function: as expected the baseline expression of p53 on day 0 was undetectable (threshold: mean fluorescence intensity <100), but by day 1, a clear-cut increase in the percentage of p53 expression was observed (increased from 100 to 600%).
Indeed, when the basal LVI excursion was compared with the fluctuation recorded during isoproterenol administration within the same range of cardiac rate, a clear-cut increase in the LVI downstroke was demonstrated.
The organisms were considered to be producing ESBL when the zone of inhibition around any of the expanded-spectrum cephalosporin discs showed a clear-cut increase towards the clavulanic acid disc.
Indeed, the analysis of the activity of neuronal networks expressing Q555X-SynI showed a clear-cut increase in both firing and bursting activities.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com