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These studies showed a clear alteration of the learning and memory phenotypes [21], [23] [25].
Unfortunately, relatively few QTLs have been translated into critical polymorphisms within genes that can be demonstrated to show a clear alteration in the risk of tumour development.
Our results also show a clear alteration in hormone biosynthesis and suggest that even short-term CR biases expression changes toward a more feminine profile.
The microscopic morphology of the four isolates was similar, but a clear alteration in radial growth and a significantly reduced growth rate of the resistant isolates on solid and in broth medium was observed compared to isolates 1 and 2 and to unrelated wild-type controls.
However, using in vitro growth analysis in duplicates on agar plates, the resistant isolates 3 an 4 showed a clear alteration in radial growth and a significantly reduced growth rate compared to the reference isolate and compared to the isolates 1 and 2 (Figure 4a).
Because prioritisation of all cases needing MRI is necessary, only those that will lead to a clear alteration in clinical management can be justified.
Similar(48)
Transient knockdown of RAB11A or treatment of cells with monensin, a recycling endosome inhibitor, caused a small but clear alteration of TLR9 fragmentation (Supplementary Fig S7B).
In agreement, we did not observe any clear alterations in the properties of relay neuron mIPSCs that could compensate for the greatly reduced tonic inhibition in δ0/0 mice (Herd et al., 2009).
Under induced conditions, cells with control plasmid pCM185 alone showed limited invasive growth, as indicated in Figure 4. Similarly, cells expressing rTFs with either the 3ZfFLO11/F1 or 6ZfFLO11/F2-F1 DBDs exhibited only some degree of invasive growth, suggesting that those rTFs were not effective in up-regulating the expression of FLO11 gene for a clear phenotypic alteration.
In the sections exposed to 500 μg/L BDE47, a clear morphological alteration of photoreceptor cells was observed, and in the remaining sections, no significant change (data not shown) was observed compared to the control.
Although we used independently isolated Parp-1-/ ES cell clones, a clear common alteration in the gene expression profile was observed (see Fig. 2A, and Tables 2 and 3).
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