Inactivating mutations in the Baf47 subunit, for instance, are present in the majority of malignant rhabdoid tumors, a class of extremely aggressive and lethal cancers of early childhood that arise primarily in the kidney, brain, and other soft tissues [75].
In both the BD and non-BD groups, opioids were the most common class of lethal medication.
In both the BD and non-BD self-poisoning groups, opioids were the most common class of lethal medication.
Inhibitors of mTOR function can block tumor growth directly (Hidalgo & Rowinsky, 2000), and it is plausible that direct effects on tumors may contribute to lifespan effects in mice, in which tumors are the most frequent class of lethal illness (Miller & Chrisp, 2002; Lipman et al., 2004).
Advocacy groups like Amnesty International have argued that Tasers, the most widely used of a class of weapons known as electrical control devices, are potentially lethal and that stricter rules should govern their use.
N-tert-butyl-N,N′-diacylhydrazines, mimicking the action of 20-hydroxyecdysone to activate the ecdysone receptor, lead to lethal premature molting, thus constituting a class of insect growth regulators useful in crop protection.
A class of genetic balancer, the reciprocal translocation, can be used to stably maintain a specific lethal mutation disrupting an essential gene by preventing recombination between the wild-type homolog and mutation-bearing chromosome.
Benzodiazepines and antidepressants were the next most common classes of lethal substances used among people with BD and were also the most common classes present in the body at time of death.
Chemical warfare agents (CWAs) constitute one class of such lethal weapons for potential use by terrorists.
The recent discovery of broadly neutralizing human monoclonal influenza antibodies [1] and the demonstrated efficacy of a representative of this novel class of antibodies against lethal viral challenge in a clinically relevant model, as presented in this paper, create an opportunity for the prevention and treatment of influenza infections, regardless of the causal strain.
