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Zoledronic acid, sold by Novartis under the name Zometa, is one of a class of bone drugs known as bisphosphonates.
In our search for additional functional motifs, we found that a class of bone marrow homing peptides BMHP [20] could be one of the most promising family candidates for stimulating NSC adhesion and differentiation.
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Dr. Verfaillie says she has found a new class of bone marrow stem cell that can grow into each of the three major lineages of body cells, and into many subtypes of cell as well.
ACP and ACP/biopolymer composites have emerged as a new class of bone tissue engineering scaffold materials.
Although no bone adhesive is established for practical use in clinical practice yet, there is evidence in vitro and in vivo that a new class of bone adhesives based on alkylene bis(dilactoyl -methacrylates may meet the requirements to bridilactoyl -methacrylatesh and bedside.
Porous mesopore-bioglass (MBG) scaffolds have been proposed as a new class of bone regeneration materials due to their apatite-formation and drug-delivery properties; however, the material's inherent brittleness and high degradation and surface instability are major disadvantages, which compromise its mechanical strength and cytocompatibility as a biological scaffold.
Mundy et al. [ 6] considered statins a class of previously unknown bone anabolic agents.
An historical example is the use of Bisphosphonates for dental purposes: Bisphosphonates (BPs) are a class of drugs that inhibit bone resorption and they are successfully used across a wide range of medical disciplines for bone diseases (Molvik & Khan 2015; Costa 2014; Anagha & Sen 2014; Giusti 2014; Bhatt et al. 2014; Eriksen et al. 2014).
Bioactive glasses represent a class of attractive materials in bone reconstruction.
For example the development of bisphosphonates, the most successful class of bone active agent, owes a debt to research on hypophosphatasia.
This article examines each class of bone grafting material based on some of the studies in each of the following categories: safety, animal research, periodontal and maxillofacial applications, skeletal grafting, and attempts to qualify the efficacy of each class of material.
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Justyna Jupowicz-Kozak
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