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Exact(42)
For example, replacement of the non-charged residue in CHR with a charged residue, or vice visa, may cause electrostatic repulsion or attraction, resulting non-optimal helix packing and/or docking.
Additionally, the fact that many NLPs (26%) have non-charged residues at position 139 raises the question if a charged residue is necessary at this position.
More than half of the SOD1 proteins studied here represent mutations affecting a charged residue or introduce a charged amino acid in place of a non-charged (Fig. 3).
It appeared that variants containing a charged residue at this position, Y527D (E) and Y527R, lost the transport activity.
Water molecules close to a charged residue are restricted from free rotation due to the interaction between their dipole moments and the electric field.
In this study, three alamethicin analogs possessing a charged residue (His, Lys, or Glu) on their N-termini were designed with the expectation of stabilizing the transmembrane structure.
Similar(18)
The mutation M180K in TP53I3 has a Miyata score of 2.63 and predicts a change from a hydrophobic to a positively charged residue.
Lys-155 in the α3 subunit, which is a positively charged residue, forms a salt bridge with the negatively charged Asp-11 of LvIA.
By comparison, the D65V mutation substitutes a polar charged residue with a non-polar residue on the hydrophobic side of the β-sheet.
E80A is a conserved charged residue as a control.
The motif consists of a positively charged residue and a polar residue that specifically interact with the negatively charged phosphodiester groups of the lipids (Palsdottir and Hunte, 2004).
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