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The final outcomes were labeled as a characterization of compounds using derived properties X from AM1 calculations and regression with MLR, using measurements Y as response.
In order to perform this analysis in metabolic networks, we used the molecular signature descriptor, a 2D representation of molecular graphs that provides a characterization of compounds and reactions in the network.
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DNA microarray – based expression profiling has been used as a genomic approach for the characterization of compounds with estrogen-like activities.
Microarray technology offers the ability to query the entire genome after exposure to such an array of compounds, permitting a characterization of the biological effects of such exposures.
The characterization of compounds produced in such an automated high throughput process, places significant demands on laboratory workflow; chromatographic methodology; instrument capacity; and data capture, processing and storage.
This battery of in vitro tests is a powerful, simple, and rapid tool that enables the characterization of compounds present in environmental compartments.
Also, this plant can be a good source for further purification studies for isolation and characterization of compounds related to these antioxidants, antidiabetic and antibacterial activities.
A cell-based screening of an in-house quinoline-derived compound collection led to the characterization of compounds exhibiting both activities in the nanomolar range on mesencephalic dopaminergic neurons in spontaneous or 1-methyl-4-phenylpyridinium (MPP+ -induced neurodegeneration.
Treatments for Alzheimer's disease, Parkinson's disease, and ALS are extremely limited, and therefore, the discovery and characterization of compounds that modulate ER stress mechanisms would represent an important step toward the development of therapeutics for these disorders.
The CNiFERs presented here were developed to facilitate pharmacological screening, potency rank ordering and characterization of compounds for calcium permeable ligand-gated ion channels (LGICs), with a particular focus on the homomeric α7 and heteromeric α4β2 nAChRs.
Characterization of compounds was done by 1H, 13C NMR Spectra, and melting point determination (for solids).
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