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Voided urine obtained immediately after DRE is greatly enriched in prostatic cells (about 80%) and thus represents a challenging starting material for biomarker discovery in oncological research.
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Bank of Scotland chief economist Donald MacRae said businesses had a "challenging" start to the third quarter of the year.
Thereafter sales were negatively affected by unseasonably hot weather which continued into September, resulting in a challenging start to the autumn season.
Watching the mother-calf pair in front of us, it seems like a challenging start to life, dodging between amorous males, whale-watching vessels, ferries, cruise ships and even well-intentioned researchers.
Things get off to a challenging start when you're immediately bitten by a zombie, but then a bunch of bedraggled survivors rescue you and take you back to their safe house.
Nick Compton is taking an indefinite break from cricket following what the England batsman's county side, Middlesex, have described as a "challenging start to the 2016 season, both physically and mentally".
Mike van Dulken at Accendo Markets said: Tate & Lyle is today's Tesco after delivering a profits warning linked to a challenging start to the year following supply chain disruption and increased competition.
Jim Balsillie, co-chief executive, said the fiscal year had "gotten off to a challenging start" and the slowdown the company experienced in the first quarter was continuing into the second quarter.
Fiscal 2012 has gotten off to a challenging start.
It's been a challenging start to 2017 for Xiaomi.
"The health board has had a challenging start to the financial year and has reported an overspend of £7.468m to the end of July.
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