The complex regulation of the pathway, together with the multiple mechanisms by which it can be activated, make this a highly challenging pathway to target.
Experimental evolution recapitulates post transfer optimization of a challenging catabolic pathway.
In summary, our results highlight the important role of evolutionary refinement in the horizontal transfer of a challenging catabolic pathway.
A separate new important issue, potential toxicity of nanomaterials and nanoparticles involving new and challenging pathways of toxicity, was included in the project at the mid-term.
Among the many signaling pathways involved in maintaining GSC stemness, tumorigenic potential, and anti-apoptotic properties, the PDK1/Akt pathway is a challenging target to develop new potential agents able to affect GBM resistance to chemotherapy.
Characterizing Makers and their pathways is a challenging endeavor.
Experimentally validating associations between ADRs and pathways is a challenging task since true validation is likely to require in-vivo experiments similar to clinical trails of drug candidates.
The discovery of pathways is a challenging problem and its solution to a large extent relies on the identification of causal molecular interactions in genomics data.
The discovery of molecular pathways is a challenging problem and its solution relies on the identification of causal molecular interactions in genomics data.
Thus, locating a substrate for a particular TOMM pathway can be a challenging endeavor.
