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In many cases, the lag in insulin initiation can present a challenging hurdle, especially when insulin becomes the next treatment option (44, 47, 48).
Because the identification of the transcription initiation region is such a challenging problem, it is not yet a common practice to integrate transcription start site prediction in genome annotation projects.
Forecasting the initiation of future eruptions is a challenging but rewarding task in volcanology.
However, the identification of master genes and key biological processes involved in the initiation of liver compensatory growth after removing the ventral lobe remains a challenging task.
Whether a dosage adjustment during the early initiation of treatment could be of benefit in terms of response is a challenging question.
Determining the level of risk (measured as number of risks) triggering the initiation of referral pathways to the corresponding mental and social services of each health centre is a challenging task.
after a challenging summer.
And a challenging business.
It needs a challenging headliner.
Was it a challenging experience?
It is a challenging task.
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