Sentence examples for a challenging dose from inspiring English sources

An adaptive response has been demonstrated after a primer dose in the range of 0.1 to 50 cGy followed 24 to 48 hours later by a challenging dose in the range of 1 Gy (Stecca and Gerber 1998; Broome et al. 2002).

In C57Bl/6 mice, an adaptive response was observed with a priming dose of 5cGy given between 1 and 7 days before the challenging dose, who disappeared when the delay between the priming and the challenging dose increased above one week, in favor of a transient feature (Ito et al. 2007).

as challenging dose.

They were then irradiated at 5 hpf by alpha particles using a planar 241Am source with an activity of 0.1151 μCi for 24 s (priming dose), and subsequently at 10 hpf using the same source for 240 s (challenging dose).

ERK phosphorylation is known to increase following exposure to low and high doses of ionizing radiation and may play a role in regulating the adaptive response of low-dose radiation to high challenging doses [28], [29].

The microscopist is obliged to keep the imaging area centered during tilting as well as to maintain accurate focus in the tilted image while minimizing the overall electron dose, a challenging and time consuming process.

"[It was] a challenging environment, challenging times.

Catalytic metallodrugs offer the prospect of low-dose therapy and a challenging new design strategy for future exploration.

Incorporation of this escalated dose of daunorubicin in the post-remission therapy is a challenging option, but increased cardiotoxicity may result from this dose intensification [ 30].

Consequently, optimization of dose and image quality offers a challenging area of research.

The six-dose regimen is highly effective and represents a challenging comparator for any new agent [13] [20].