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Cuff tear arthropathy remains a challenging clinical problem, quite debilitating for the patient and a significant management challenge for the shoulder surgeon.
Massive segmental defects arising from trauma or tumor resection remain a challenging clinical problem.
Management of massive segmental bone defects remains a challenging clinical problem and bone marrow-derived mesenchymal stem cells (BMSCs) hold promise for bone regeneration.
Lumbar axial back pain arising from degenerative disc disease continues to be a challenging clinical problem whether treated with nonsurgical management, local injection, or motion segment stabilization and fusion.
Management of Pauwels type-3 vertical femoral neck fractures has been a challenging clinical problem as they experience high shear forces and thus a greater risk of treatment failure.
BACKGROUND: Pulmonary artery reconstruction remains a challenging clinical problem.
Similar(43)
Clinically nonfunctional pituitary adenomas (NFPAs) are a very challenging clinical problem in pituitary tumor patients relative to functional pituitary adenomas (FPAs) because an NFPA does not have any elevation of the corresponding hormone [ 1, 2].
Wound healing impairment represents a particularly challenging clinical problem to which no efficacious treatment regimens currently exist.
Malignant glioblastoma represents a particularly challenging clinical problem because these cells migrate avidly along many routes beyond the boundaries of the main tumor mass.
Brain metastasis has become an increasingly challenging clinical problem, largely due to the recently improved clinical control of systemic metastatic diseases, exemplified by the use of trastuzumab (Herceptin) for HER2-positive breast cancer.
I shared my own thoughts and experiences, and without identifying the patient, I discussed the situation with my wife (who is also a therapist, and a helpful editor), as I do when confronted by an ethical or otherwise challenging clinical problem.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com