Such scenarios create an ethical challenge, implicating the patient's autonomy and right to choose, the need to be protected from harm if discharged to an environment in which the patient cannot function safely, as well as issues related to just allocation of resources and the right to fair and equitable access (Beauchamp and Childress 2012).
These challenges implicate how school leaders understand the connections between TSRs and student outcomes.
We evaluated how these concepts cope with challenges implicated by personalized medicine.
The complex nature of the reported association illustrates the challenge of implicating a specific gene and mutation in the causation of polygenic disease.
Immunization via skin, however, with identical PQ-cure cycles, reduces protection [129] even against intravenous challenge, again implicating the skin in inefficient development of immunity.
The complex design of the elevator mechanism in duodenoscopes has been recognized as a challenge for disinfection and recently implicated as a potential source of persistent bacterial contamination.
Sifting through these somatic single nucleotide variants (SNVs) to pin down the few driver mutations implicated in cancer is a challenge.
During fights, both Nazca booby hatchlings facultatively upregulate testosterone [T; 3], in accord with the Challenge Hypothesis [2], implicating testosterone in a quick and forceful transition to combat.
Of note, antibody-mediated neutralization of IL-17A conferred protection from hepatocellular damage in WT mice challenged with an HFD, specifically implicating IL-17A, among the diverse IL-17 family member ligands for IL-17RA, in obesity-related hepatocellular damage (Fig. 2C).
Addition of an NO scavenger before NO challenge duplicates IAR, implicating reactive nitrogenous species in cell death.
Addition of uric acid (a peroxynitrite scavenger) before cytotoxic NO challenge, duplicates IAR, implicating peroxynitrite, with subsequent 3NY formation, in cell death, and abrogation of this pathway as a mechanism of IAR.
