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The best way to get your arms around this concept is to do a "Challenge-Approach-Results" exercise.
From this study, Salmonella Typhi challenge appears to fall into the latter category, the features of which are seen as desirable prerequisites for using a human challenge approach to assess vaccine and therapeutic efficacy.
This issue, along with the biochemical and physical complexity of the ECM, poses a challenge when approaching ECM involvement in biological processes including IBD pathogenesis.
The idea was that a challenge-based approach would bring together resources and knowledge across different fields, technologies and disciplines, including social sciences and the humanities.
Infusing HDL or apoA-1 presents a conceptually simple, but challenging approach.
Choosing a suitable timeout value for different kinds of network configuration may be a challenge if this approach is adopted.
My daughter's camp employs a "challenge by choice" approach.
However a challenge with this approach is deconvoluting virulence-relevant and -irrelevant effects.
United commonly have greater prizes in mind than that or the Carling Cup but today's victory is a fillip as the true challenges approach.
A challenge with distributed approaches is the lack of a global view of the infrastructure, which impact the ability to reach a globally optimal solution.
However, sampling of kinetically distinct substates remains a challenge to these approaches.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com