In order to achieve the goal of the desired survivorship rates of cementless TSA a chain of modification of the initial BioModular® prosthesis was employed with eventual evolvement of the current Nottingham TSR design.
Four main changes — higher plant density, slower rate of leaf appearance, lower nitrogen content, and reduced size of all organs — induced by the aerobic crop environment were responsible for three chains of modifications that resulted in lower biomass accumulation and finally lower grain yield.
To integrate the TPM into the boot process and establish the chain of trust, modifications to the system are required.
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As the chain polymerizes, it undergoes a series of modifications; the initial modification reactions involve removal of acetyl groups from GlcNAc residues, followed by sulfation of the amino group which is catalyzed by four different isoforms of N-deacetylase/N-sulfotransferases: NDST1-4 [ 13, 14].
The quenching of 1O2 by Trp, His, Tyr, Met, and Cys side-chains can result in a number of modifications to ECM-protein structure and therefore function (reviewed in [56]).
Terminal alkyne modifications were employed in place of the C20 27 aliphatic chain of cholesterol since modification at this position can be tolerated in ShhC autoprocessing.
In 2009, Read and colleagues [13] introduced "classifiers chain", a modification of binary relevance that would take into account interactions between labels.
However the length of the side chain, modifications of amino acids and occurrence of additional functional groups are unknown.
A mechano-chemical chain of events recruiting calcium homeostasis, extracellular matrix modifications, and cytoskeletal dynamics governs cellular mechanotransduction.
