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The accumulated data suggest that when a certain lineage of cells is unable to produce a normal/functional signaling protein, such cells increase their production of defective transcripts in an attempt to compensate for the defective isoform.
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The VS log-odd score corresponds to the logarithm of the ratio between the probability of a certain lineage to be VS and its contrary (to be UVS) given the ω-lineage.
Terminally specified cells of a certain lineage represent only a minor cell fraction of the differentiating ESCs in culture.
To assess the significance of gene duplication in each of the maturation pathway enzymes, alternative trees constraining two or more separate subclades of a certain lineage as a monphyly were obtained by 20 searches using RAxML [ 67] with the models mentioned above.
Depending on HAmo LINE2, multiple source genes (subfamilies) of HAmo SINE actively expanded and underwent retroposition in a certain lineage or within the whole family of Cyprinidae.
The above analysis indicates that multiple source genes (subfamilies) actively amplified within a certain lineage or within the whole family of Cyprinidae.
The hundreds of SINE sequences found in our study revealed that multiple source subfamilies actively expanded and underwent retroposition within a certain lineage or within the whole family of Cyprinidae.
Four subfamilies (type I, II, III and IV), which were divided based on diagnostic nucleotides in the tRNA-unrelated region, expanded preferentially within a certain lineage or within the whole family of Cyprinidae as multiple active source genes.
Clearly, the number of LSRs in a certain lineage is mostly affected by its closest related lineage being compared.
Pointing out the oligonucleotides whose occurrence is peculiar commonly (and thus stably) in a certain lineage should provide information concerning biological roles of these oligonucleotides in the lineage.
These findings imply that targeting transcription factors may be one of strategy for controlling the commitment and differentiation of MSCs to a certain lineage.
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