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"There's a certain delicate tension between a clinician taking a technology that's proven for a certain indication and learning by experience that it is useful for patients that exceed those limits," Dr. Tunis said.
Their input into go/no go and priority setting decisions can reveal that further development of a drug is unattractive from an economic viewpoint, or that developing a certain indication is more attractive than another.
Gold is another up to 0.15 gram per kilogram (4.5 ounces per ton) of plants—not economically feasible to mine but a certain indication of the availability of such ore deposits in the soil.
Such indirect methods can be used to achieve a certain indication, but do not give specific information about the actual amount of product as the surface tension could be lowered by several other surfactants produced by Bacillus (e.g. Iturin or Fengycin).
Table 1 shows the information regarding whether each country reimburses a certain indication, and if reimbursed, when each country first approved the reimbursement.
Upregulation of Wnt5a Wisp1, and other genes from Wnt signaling in our experiments could give a certain indication that the regulatory mechanism could be related in both cases.
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Excluded as inputs were ORs for condensation (a less certain indication of potential microbial contamination), ORs per unit area of visible mold or water damage, ORs for "suspected moisture problem," and ORs for higher measured airborne concentrations of molds, bacteria, ergosterol, glucan, or endotoxin.
Evidence shows certain indication that leads to a decision with more or less uncertainty.
It has been shown that retrospective analysis of appropriateness criteria is feasible but is found to be imprecise when adjudicating patients to certain indication groups [ 37].
In its review of election-related advertising, Facebook said it had also found an additional 2,200 ads, costing $50,000, that had less certain indications of a Russian connection.
This shift may have a significant beneficial effect in certain indications, such as shock, and result in maintenance of vital organ perfusion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com