Data obtained to date show that DNA DSBs repair is down regulated in certain differentiated cells such as hematopoietic cells [51], [52] or jejunum epithelium [51].
There is ample evidence that certain differentiated hematopoietic cells, including macrophages, T cells, and mast cells, are incorporated into the tumor microenvironment [1], [2]; however, a systematic investigation of the composition of the hematopoietic compartment of the tumor stroma has not been carried out.
In accordance with in situ hybridization data, PEVE is detected in certain differentiated parenchyma cells.
Local perfusion can also play an important role in choline uptake in tumour tissue, as has been suggested for liver hepatocellular carcinoma [ 9] and certain differentiated tumours of brain and lung [ 10, 11], or in infection and inflammation [ 12, 13].
An inheritable pattern of carcinogenesis is possible for certain differentiated non-medullary thyroid cancers, but shared environmental exposures may also explain the parent-child associations of cancer in this study.
Therefore, K5/14 pair is expressed in more than just corneal epithelial stem cells, and must also include a certain amount of differentiated corneal epithelial cells.
The tail bud is formed from parts that have already been differentiated to a certain extent; prolongations of the neural tube and of the notochord are involved, and endoderm extends into the tail rudiment as the postanal gut, which, however, soon degenerates.
The chromosomes are indistinguishable in different stages of both mitotic and meiotic divisions, except for orcein stained pachytene, where different bivalents can be differentiated to a certain degree.
That is, the primitive cells divide and give rise to cells that are differentiated to a certain degree, at least during the earlier stages of the disease.
They're well defined and differentiated, albeit within a certain, whiny, upstart-shrimp, loser-to-psychopath range.
