This finding is not unexpected as previous studies demonstrate an increase in certain adverse events when stable subjects are switched to a new therapy.
Whereas treatment with parenteral oestrogen may represent an advance for certain adverse effects of ADT as well as possibly being more cost-effective, evidence is still lacking.
3 Although the differences were not significant, these findings prompted the United States Food and Drug Administration to issue a drug safety communication about a possible increased risk of certain adverse cardiovascular events associated with varenicline.
Furthermore, an increased susceptibility to certain adverse drug reactions may partly be due to genetic polymorphisms that alter responses of individual persons to various drugs [ 13].
Registries can also be limited by comprising a population that is not as "sick" as the general CD population, possibly leading to an under-representation of certain adverse events.
Categorizing a woman as having GDM with a glucose tolerance test (GTT) identifies the top 5 10% of a continuum of risk for certain adverse pregnancy outcomes.
It has been believed for over 30 years that HLA type is a predictor of risk for certain adverse drug reactions, and well-established and replicated associations have now been described for both DILI, including some reactions that do not show obvious features of a hypersensivity reaction, and hypersensitivity reactions affecting the skin.
10, 11 For a variety of reasons (eg, increased sensitivity to certain adverse effects, potential difficulty with adhering to a regimen, reduced ability to recognize and report adverse events) the risk of ADR may be less favorable in AD patients as compared to those without dementia.
However, certain adverse events are a mandatory consequence of the conditioning regimen administered prior to allo-HSCT.
