The phrase "a central question concerns" is correct and usable in written English.
It can be used when introducing a key issue or topic that is the focus of discussion or analysis.
Example: "In this research paper, a central question concerns the impact of climate change on biodiversity."
Alternatives: "a key issue relates to" or "a primary concern involves".
Because several codon choices are available for a given amino acid, a central question concerns whether viral sequences have evolved to optimize not only the protein coding consensus, but also the DNA/RNA sequences accessible through mutation.
In particular, a central question concerns the validity of biomarkers (and surrogate markers) and activity indices, which are pertinent for evaluating the performance of lupus trials [ 63, 64].
Just as a central issue concerning acceptability judgment data concerns its reliability as evidence for empirical generalizations about languages or idiolects, a central question concerning the collection of corpus data concerns whether or not it is representative of the language variety it purports to represent.
Still, the central question concerns the C.I.A.'s prewar assessment of Iraq's purported stock of weapons of mass destruction.
One central question concerns the mechanism by which CTLA-4 can induce T-cell non-responsiveness without a concurrent induction of antigen induced cell death (AICD).
Since anergy often leads to increased apoptosis, one central question concerns how CTLA-4 can anergize and maintain tolerance without inducing T-cell death.
One central question concerns the signaling mechanism used by CTLA-4 to induce long-term anergy and prevent the induction of cell death.
One central question concerns the extent to which climate changes and recent global changes due to human disturbances (e.g., land-use management and fragmentation) affect gene flow (Manel and Holderegger 2013).
To the political philosopher, the central question concerning political authority is: Under what conditions can state action be considered legitimate?
The following central question concerning the functions spaces behind the Schrödinger equation (1.21) is open and shall be partially attacked in the sequel.
A central question within contemporary personality theory concerns whether one, two, three, or five factors mark the apex of this hierarchy (Ashton et al., 2009, see top section of Figure 2; Ferguson, Chamorro-Premuzic, Pickering, & Wiess, in press).
