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The phrase "a central problem in understanding" is correct and usable in written English.
It can be used when discussing a key issue or challenge that affects comprehension of a topic or concept.
Example: "One of the central problems in understanding climate change is the misinformation spread by various media outlets."
Alternatives: "a key issue in grasping" or "a fundamental challenge in comprehending".
Exact(1)
Protein subcellular localization is a central problem in understanding cell biology and has been the focus of intense research.
Similar(59)
These letters illustrate one of the central problems in understanding the Pahlavi finances -- determining the dividing line between the Pahlavi private fortune and the government's funds.
Understanding the mechanisms driving biological diversity remains a central problem in ecology and evolutionary biology.
Understanding bounds for the effective differential Nullstellensatz is a central problem in differential algebraic geometry.
Understanding the factors underlying this enormous variability is a central problem in evolutionary biology.
Motivation: Discovering and understanding patterns in networks of protein protein interactions (PPIs) is a central problem in systems biology.
Understanding the evolutionary forces that produced the human brain is a central problem in neuroscience and human biology.
Understanding interactions between mutations and how they affect fitness is a central problem in evolutionary biology that bears on such fundamental issues as the structure of fitness landscapes and the evolution of sex.
Understanding how selection and genetic drift have shaped the composition of proteins is a central problem in population genetics and molecular evolution.
A central problem in the preparation of new advanced materials, and particularly those based on complex molecules such as liquid crystals, is understanding the relation between molecular structure and material properties.
Understanding how the timekeeping of molecular clocks is employed by networks of clock neurons to orchestrate rhythmic behavior is a central problem in chronobiology.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com