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The phrase "a central point of difference" is correct and usable in written English.
It can be used to highlight a significant distinction or disagreement between two or more subjects or ideas.
Example: "The study revealed a central point of difference between the two theories, which could lead to further research."
Alternatives: "a key distinction" or "a main point of divergence".
Exact(1)
Mr Rudd had made this a central point of difference from the Howard government's subservience to President Bush's refusal to ratify.The Indonesia visit will also highlight Mr Rudd's talk of pursuing closer economic and humanitarian engagement with Australia's neighbourhood.
Similar(59)
A central point of information clustering.
2014 is the year that work became a central point of discussion in Silicon Valley.
This is a central point of our work.
A central point is the derivation of analytic expressions for breakage and coalescence rate distributions.
Health Motivation (HM) is a central point in the theory of Health Preventive Behaviour [ 12].
The strategy was based on a 24 full factorial design with a central point followed by the addition of star points in a face-centered central composite design.
eReferral to a central point was a key element of the strategy [ 7, 48].
A central point in this theory is the use of opinion leaders as 'change agents'.
The relevance of the model should be a central point in the evaluation stage.
Once again, a central point is misconstrued.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com