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Liver is a central nexus integrating metabolic and immunologic homeostasis in the human body, and the direct or indirect target of most molecular therapeutics.
While Honolulu is mostly thought of by Americans as a tourist destination, it's also a connective port between Asia and the United States, making it a central nexus of business, immigration and the military.
There are, of course, exceptions to this: the NRA, for example, provides a central nexus of information and influence to (mostly Republican) gun rights supporters that's far more influential amongst their constituency than any environmental organization is amongst environmentalists.
There are therefore a variety of theoretically possible mechanisms whereby differential PGRMC1 abundance and phosphorylation could affect tumor biology, perhaps with a central nexus functionality.
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A current exhibition, Set Theory : Roland Reiss, curated by Max Presneill at the Torrance Art Museum, celebrates Roland as a central nexus-point artist and includes artists, like myself, who have had "overlapping personal dialogues" with Roland.
8, 9 Therefore, mTOR is the central nexus in a series of signaling pathways that integrate intracellular nutrient, energy, and redox needs with extracellular amino acid, nutrient, growth factor, and cytokine availability.
Skype is a peer-to-peer service with no central nexus to tap into.
As often happens with Pamuk, this (confused) love story, which revolves around a stash of ambiguous love letters, is sometimes outshone by a more abiding relationship with Istanbul itself -- previous books such as "The Museum of Innocence," his memoirs, "Istanbul" and "The Black Book" all revolve around Pamuk's central nexus of inspiration.
Their central, "nexus," genes were singled out as potential regulators that may cause the disease phenotype [ 45].
Although Aβ is still clearly implicated in AD, the field has been prompted to consider alternative hypotheses beyond Aβ as the central nexus of AD.
Gradually, it has been appreciated that dsx could no longer be viewed as the master-switch gene orchestrating sexual development and behaviour in each cell, but instead should be viewed as the interpreter for the sexual identity of the cell, expressing this identity only on request, making dsx the central nexus of insect sex determination.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com