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A central difficulty is the uneasy relationship between Belgrade and the other Yugoslav republic, Montenegro.
A central difficulty is that the data used to "train" detection algorithms are unique and relatively brief historical samples and thus do not represent the full range of possible background scenarios.
[ 3- 6] Some of the challenges of applying RCT designs to homeopathy have been described by other authors.[ 7, 8] A central difficulty is that the placebo-controlled RCT has low external or "model" validity in relation to the practice of homeopathy in real-world contexts.
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The central difficulty is that in a field it is possible to divide but in a ring it is not.
The central difficulty is to ensure that no new loops are created inside the plugs themselves.
One central difficulty is that very few of the people arrested for hooliganism abroad are ever prosecuted.
David Leventhal, one of two Romeos in the alternating title pairings, said that the central difficulty was to find a way to communicate the story's strong emotions without using a ballet vocabulary.
As the stellar core continues to shrink and the central temperature and density are forced even higher, a fundamental difficulty is soon reached.
A central difficulty of falsification is behavioural rather than theoretical – falsificationism is an ideal.
A central difficulty of utopian fiction is the lack of dramatic conflict; a state of perfection is inherently uneventful.
A central difficulty in evolution education is that many of the "classic" examples found in textbooks and other outlets (e.g., Darwin's finches, peppered moths, the evolution of horses) seem irrelevant to everyday experiences of most people (Hillis 2007; Thanukos 2009).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com