The phrase "a central difficulty in" is correct and usable in written English.
It can be used when discussing a primary challenge or issue within a specific context or subject matter.
Example: "A central difficulty in understanding climate change is the complexity of the scientific data involved."
Alternatives: "a key challenge in" or "a major issue in".
But there was a central difficulty in winning over the Russians.
A central difficulty in evolution education is that many of the "classic" examples found in textbooks and other outlets (e.g., Darwin's finches, peppered moths, the evolution of horses) seem irrelevant to everyday experiences of most people (Hillis 2007; Thanukos 2009).
Although the influence of genetic susceptibility to CRC is well documented, a central difficulty in the identification of the genetic factors influencing CRC is the inability to adequately cope with the phenotypic heterogeneity present in all complex diseases.
A central difficulty of falsification is behavioural rather than theoretical – falsificationism is an ideal.
Beth Cooke expressively captures her turmoil, yet there is a central difficulty with the characterisation of Karin.
A central difficulty is the uneasy relationship between Belgrade and the other Yugoslav republic, Montenegro.
One central difficulty in the interpretation of volcanic fatality data, and likely fatality data pertaining to other natural hazards, is the major influence of a small number of incidents causing thousands of fatalities.
One central difficulty in defining clathrin-independent endocytic pathways has been the paucity of rigorously validated endocytic markers and pathway-specific cargoes.
The central difficulties in constructing such information measures arise from the multiple, and sometimes conflicting, aims in practice.
The back-and-forth underscored one of the central difficulties in resolving the crisis: while opposition activists and armed groups refuse to negotiate until the government stops its crackdown, Mr. Assad's government says it has the right to respond with force to armed attacks.
The findings of this study demonstrate that one of the central difficulties in monitoring patient safety issues and preventing patient safety incidents for people with intellectual disabilities is the trend for reporting and monitoring those patient safety incidents that result, or could have resulted, in clearly defined physical harm.
