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A central bottleneck is that most recurrently mutated genes in cancer are found mutated in fewer than 5% of patients and most individual variants are found at exceedingly rare frequencies.
Distributed approaches also benefit from the local optimization that is independent of a central bottleneck.
The results provide strong evidence that machine learning techniques can bypass a central bottleneck that interferes with turning unstructured data into useful information.
While brain evidence for a central bottleneck in the frontal lobes has been reported before (e.g., [48]), the current fMRI results give evidence for an additional central bottleneck located in the intraparietal sulcus, corroborating multiple-bottleneck theories.
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Thus, the use of relatively simple, independent visual and auditory stimuli (one-syllable words) that required unspeeded responses, led to an AB within but not between modalities, which strongly suggests the existence of modality-specific limitations rather than an amodal, more central bottleneck.
One theory, the central bottleneck, suggests that there is an amodal 'unified' processing bottleneck slowing response due to competition and interference by the two tasks, regardless of executive function processing or type of storage [ 5, 6].
This in contrast to for instance the EPIC theory [46], which assumes only peripheral bottlenecks, and the central bottleneck theory of [47], which assumes only a single central bottleneck.
Our results support the central bottleneck theory and suggest that the dlPFC is an important mediator of neural activity for both short-term storage and executive processes.
Our results support the central bottleneck theory and suggest that the dorsolateral PFC is an important mediator of neural activity for both short-term storage and executive processes.
There would be no one central bottleneck that could fail.
In this context, we will investigate the memory footprint, which is the central bottleneck of global flooding methods.
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