Sentence examples for a cell based model of from inspiring English sources

Our transcript profiling experiments identified a number of transcription factors that showed reduced expression in response to a loss of Prlr, but profiling of a cell based model of positive Prl action identified the ets transcription factor Elf5 [ 47].

The impact of caspase cleavage was confirmed in a cell based model, showing that predominantly caspase-1-mediated fragmentation of expanded ataxin-3 resulted in increased aggregation and treatment with caspase inhibitors prevented inclusion formation in vitro [ 61].

Since TF is recognized as the initiator of coagulation in vivo according to the cell based model of haemostasis, TF activated TEG analyses may provide a better in vitro estimate of in vivo coagulation.

In particular, in vitro cell based model of BBB where cerebral endothelial cells are co-cultured with other components of the NVU such as pericytes or astrocytes (co-cultures and triple co-cultures systems) [ 103] should be considered for evaluation.

Cell based models of coagulation (CBM) have provided mechanistic insight into numerous hematological issues for nearly two decades.

Using these selective ER subtype agonists, we show that ERβ mediates the stimulation of calcium oscillations in neurons derived from mouse and human ES cells, which demonstrates that these neurons might be a useful cell based model to study the role of ERs and the nongenomic mechanisms of estrogens.

This novel in vitro assay provides a realistic human cell based model for basic science studies, identification of new treatment targets, selection of pathways to target validation, and rapid screening of candidate agents.

A new Monte Carlo model generates a physical space with the complex geometry of human tissue or a cell culture based model of tissue, which is affected by the passage of ionizing radiation.

One obstacle to investigating the actions and roles of ERβ in neurons is the lack of cell based models.

It is a single-cell based model, where the evolution of each tumor is described in terms of the evolutionary dynamics of its constituent cells.

Clearly TGF-β1 is not the only regulator of epithelial cell behaviour but to the best of our knowledge this is one of only a few such multi-scale models which seek to link intracellular signaling to an agent based model of cell behaviour (as referenced in the accompanying paper).