Sentence examples for a cell based model from inspiring English sources

In our attempt to study the biological role of Gas6 and Axl signaling in a cell based model system, we first verified the expression and functionality of Axl and Gas6 in the ccRCC 786-O cell line deficient in the VHL tumor suppressor protein.

PREVENT was a cell based model developed by Gunning-Schepers in the Netherlands during the 1980s [ 23].

More recently, a cell based model has been proposed that differs from previous models primarily by emphasizing the cellular control of coagulation in vivo (Fig. 1) [ 11].

The impact of caspase cleavage was confirmed in a cell based model, showing that predominantly caspase-1-mediated fragmentation of expanded ataxin-3 resulted in increased aggregation and treatment with caspase inhibitors prevented inclusion formation in vitro [ 61].

To demonstrate that these SIRT1 activators can directly increase mitochondrial content in a cell based model, we measured CS activity in C2C12 myotubes treated with vehicle, SRT501 or SRT1720 for 48 hours.

Our transcript profiling experiments identified a number of transcription factors that showed reduced expression in response to a loss of Prlr, but profiling of a cell based model of positive Prl action identified the ets transcription factor Elf5 [ 47].

A biomechanical, cell based model was developed that describes both individual cell behavior and cell-environment interaction based on cellular mechanics.

Using these selective ER subtype agonists, we show that ERβ mediates the stimulation of calcium oscillations in neurons derived from mouse and human ES cells, which demonstrates that these neurons might be a useful cell based model to study the role of ERs and the nongenomic mechanisms of estrogens.

The Coronary Heart Disease Policy (CHDP) Model is a state-transition, cell based model developed in the1980s [ 13].

This novel in vitro assay provides a realistic human cell based model for basic science studies, identification of new treatment targets, selection of pathways to target validation, and rapid screening of candidate agents.

Next, we examined whether SRT501 and SRT1720 could affect inflammatory signaling in an in vitro cell based model, LPS-induced TNFα secretion in RAW264.7 macrophages.